The RELIANCE Trial provided the first demonstration of licensure-quality CAR-T manufacturing and clinical trial data generation in r/r patients originating in China. These results with relma-cel demonstrate similar preliminary response rates and PK profiles while providing the potential for an improved toxicity profile in heavily-pre-treated patients with r/r DLBCL having poor risk features relative to other CD19-specific CAR-Ts approved in the US and EU.
Co-founded by Juno Therapeutics (a Bristol Myers Squibb company) and Wuxi AppTec, JW Therapeutics is a leading cellular immunotherapy company with an integrated platform focusing on developing, manufacturing and commercializing breakthrough cell-based immunotherapies for hematological cancers and solid tumors.
JW Therapeutics’ vision is to develop innovative cell therapies for the China market to transform the treatment of cancer for Chinese patients. The company has built a comprehensive and differentiated cell therapy pipeline covering both hematological cancers and solid tumors. Its lead product, relmacabtagene autoleucel (“relma-cel”), an anti-CD19 CAR-T therapy for relapsed or refractory B-cell lymphoma, is expected to be the first CAR-T therapy to be approved as a Category 1 biologics product in China.
We have strategically built a comprehensive and differentiated product pipeline of cellular immunotherapy, covering a variety of next-generation approaches that improve the risk-to-benefit ratio of our products, including allogeneic approaches, combination strategies with small molecules and other CAR-T products with new gene modifications. We believe that our product candidates have the potential to be the ground-breaking therapies in their respective indications.